Mitomycin alkaloids: synthetic studies
| dc.contributor.author | Gubler, Daniel Alan, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.contributor.author | Rovis, Tomislav, committee member | |
| dc.contributor.author | Kennan, Alan J., committee member | |
| dc.contributor.author | Elliott, C. Michael, committee member | |
| dc.contributor.author | Luger, Karolin, committee member | |
| dc.date.accessioned | 2022-11-28T17:46:46Z | |
| dc.date.available | 2022-11-28T17:46:46Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Documented herein are efforts towards the first asymmetric total synthesis of the mitomycin family of natural products. Methods have been developed that efficiently construct eight-membered ring precursors of the natural products. Additionally, a tetracyclic mitosane compound containing all the core features of the mitomycins except the C9a methyl aminal has been constructed. The above-mentioned synthetic efforts help set the stage for future completion of the asymmetric total synthesis of this family of compounds. The studies mentioned herein, while not totally successful, shed new light on the reactivity of the mitomycins as well as the remarkable electronic effect of the electron-rich arene ring. | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier.uri | https://hdl.handle.net/10217/235854 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991011940959703361 | |
| dc.relation | QD421.G835 2009 | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject.lcsh | Mitomycin -- Synthesis | |
| dc.subject.lcsh | Alkaloids -- Synthesis | |
| dc.title | Mitomycin alkaloids: synthetic studies | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ETDF_2009_Sp_Gubler_Daniel_DIP.pdf
- Size:
- 24.54 MB
- Format:
- Adobe Portable Document Format