Relationships between objectively measured physical activity and stool metabolome in individuals at high risk for colorectal cancer
| dc.contributor.author | Beale, Melanie N., author | |
| dc.contributor.author | Leach, Heather J., advisor | |
| dc.contributor.author | Ryan, Elizabeth P., advisor | |
| dc.contributor.author | Hickey, Matthew S., committee member | |
| dc.contributor.author | Melby, Chris L., committee member | |
| dc.date.accessioned | 2019-09-10T14:36:13Z | |
| dc.date.available | 2020-09-03T14:36:14Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Physical activity is known to reduce the risk of colorectal cancer and adenomatous polyp recurrence. Targeted metabolomic profiling of the stool metabolome may provide insight to the mechanistic links between physical activity and colorectal cancer. This study utilized baseline physical activity and metabolomics data from a dietary fiber intervention for individuals at high risk for colorectal cancer. Participants (N=21), 59+/-9 years, BMI 28.1+/-3.35 wore an activPALâ„¢ accelerometer for 7 consecutive days, provided a stool sample, and a 3-day dietary log. Stool bile acids and short chain fatty acids were quantified with gas chromatography mass spectroscopy and ultra-high performance liquid-chromatography tandem mass spectrometry. Linear regression models examined relationships between light intensity physical activity minutes, moderate to vigorous physical activity minutes, MET-hours per day, and sedentary minutes, with abundances of short chain fatty acids and bile acids while accounting for dietary fiber intake. Light intensity PA minutes predicted butyrate and propionate abundance when accounting for dietary fiber. MVPA predicted deoxycholic acid and ursodeoxycholic acid abundance. These data suggest that both low intensity PA and MVPA may both have implications for colorectal cancer primary and secondary prevention through different mechanisms. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Beale_colostate_0053N_15609.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/197380 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | Relationships between objectively measured physical activity and stool metabolome in individuals at high risk for colorectal cancer | |
| dc.type | Text | |
| dcterms.embargo.expires | 2020-09-03 | |
| dcterms.embargo.terms | 2020-09-03 | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Health and Exercise Science | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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