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Application of metallacycles for the synthesis of small molecules

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dc.contributor.authorWilliams, Catherine Marie, author
dc.contributor.authorRovis, Tomislav, advisor
dc.contributor.authorWood, John L., committee member
dc.contributor.authorFinke, Richard G., committee member
dc.contributor.authorShores, Matthew P., committee member
dc.contributor.authorMcNeil, Michael R., committee member
dc.date.accessioned2007-01-03T05:34:48Z
dc.date.available2007-01-03T05:34:48Z
dc.date.issued2011
dc.description.abstractA method for the nickel-catalyzed hydrocarboxylation of styrene derivatives has been developed that affords exclusively the branched carboxylic acids in moderate to excellent yields. The reaction scope is tolerant of a variety of electron-deficient ortho-, meta-, and para-styrene analogues containing ester, ketone, nitrile, and halide functionalities. The reaction is remarkably efficient, proceeding well with as little as 1 mol% Ni(acac)2 and 2 mol% Cs2CO3. A system for carbon dioxide sequestration and release in organic polymers has been investigated. Although evidence supporting successful carbon dioxide fixation has been found, the envisioned system is not a practical means of sequestration and release. A rapid approach for the synthesis of Abyssomicin C has been developed utilizing the desymmetrization of meso-dimethylglutaric anhydride. Closely modeled after Sorensen's synthesis, our route bypasses the more inefficient beginning steps to intercept the completed synthesis at the Diels-Alder precursor.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierWilliams_colostate_0053A_10535.pdf
dc.identifier.urihttp://hdl.handle.net/10217/48168
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectanhydride desymmetrization
dc.subjectorganometallic
dc.subjectmetallacycles
dc.titleApplication of metallacycles for the synthesis of small molecules
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineChemistry
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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