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Pharmacokinetic investigation of commercially available edible marijuana products in humans: potential influence of body composition and influence on glucose control

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dc.contributor.authorEwell, Taylor, author
dc.contributor.authorBell, Christopher, advisor
dc.contributor.authorHickey, Matthew, committee member
dc.contributor.authorHamilton, Karyn, committee member
dc.contributor.authorWeir, Tiffany, committee member
dc.date.accessioned2022-01-07T11:29:10Z
dc.date.available2022-01-07T11:29:10Z
dc.date.issued2021
dc.description.abstractOur investigation of five commercially available edible marijuana products containing 10mg of delta-9-tetrahydrocannabinol (THC) aimed to describe the pharmacokinetics of these products, investigate the potential influence of body composition on THC bioavailability, and, based on epidemiological research completed in the last decade, determine if acute marijuana ingestion influences glucose tolerance when compared to a THC-free gummy. We studied seven regular marijuana users. We utilized a single-blind randomized controlled crossover study design in which participants self-administered edible marijuana or a THC-free gummy. Thirty minutes following marijuana ingestion a standard oral glucose tolerance test was initiated via consumption of a 75g glucose drink. There was, at minimum, a four-day washout period between trials. Average time to peak plasma THC concentration ranged from 35 to 90 minutes, and average peak THC concentrations ranged from 3.2 to 5.5 ng/ml. Significant differences between products were identified twenty- and thirty-minutes post-ingestion. Several measures of body composition had significant correlations with plasma THC, although none of these correlations persisted across all products. There were no differences in indices of glycemic control between marijuana products or the THC-free gummy. Following acute edible marijuana ingestion in habitual users, significant differences in THC pharmacokinetics existed between similar products, possibly due to body composition, although glucose control was not impacted. In summary, these data may inform recreational users to the proper dose for marijuana ingestion to achieve the desired outcome and to avoid overdose.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierEwell_colostate_0053N_16956.pdf
dc.identifier.urihttps://hdl.handle.net/10217/234201
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectedible marijuana
dc.subjectTHC
dc.subjectbody composition
dc.subjectglucose tolerance
dc.titlePharmacokinetic investigation of commercially available edible marijuana products in humans: potential influence of body composition and influence on glucose control
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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