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Exploring microbiome-targeted interventions in the mitigation of endothelial dysfunction

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dc.contributor.authorRisk, Briana D., author
dc.contributor.authorWeir, Tiffany L., advisor
dc.contributor.authorGentile, Christopher L., advisor
dc.contributor.authorChicco, Adam J., committee member
dc.contributor.authorFoster, Michelle T., committee member
dc.date.accessioned2024-09-09T20:52:01Z
dc.date.available2025-08-16
dc.date.issued2024
dc.description.abstractCardiovascular disease (CVD) has been the leading cause of mortality in the United States for more than seventy years eclipsing cancer and respiratory disease by more than 13%. Despite sincere efforts to decrease the incidence of CVD, various environmental and intrinsic factors contribute to CVD progression, making it challenging to mitigate this complex condition. However, the past decade has shown tremendous growth in understanding the connection between the gut microbiome in its protective, or pathogenic progression of CVD. The gut microbiome, or the consortia of microbial species, genes, and metabolites, that shapes the gastrointestinal environment has a profound impact on the vascular endothelium through mechanisms not yet entirely understood. Therefore, the purpose of the research in this dissertation was to: 1) Utilize next-generation sequencing and metabolomics to characterize microbial contribution to varied endothelial response after a dietary blueberry intervention in post-menopausal females; 2) Determine if a hypertensive microbiome after blueberry treatment confers gastrointestinal and endothelial phenotype in a humanized mouse model; 3) Evaluate the efficacy of a probiotic in reversing endothelial dysfunction in dietarily obese mice, while exploring the contribution to gut barrier integrity and vasoactive metabolite proliferation in a novel cell co-culture.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierRisk_colostate_0053A_18075.pdf
dc.identifier.urihttps://hdl.handle.net/10217/239199
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.accessEmbargo expires: 08/16/2025.
dc.subjectendothelial dysfunction
dc.subjectgut health
dc.subjectprobiotic
dc.subjectfecal transplant
dc.subjectcardiovascular disease
dc.subjectmicrobiome
dc.titleExploring microbiome-targeted interventions in the mitigation of endothelial dysfunction
dc.typeText
dcterms.embargo.expires2025-08-16
dcterms.embargo.terms2025-08-16
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineFood Science and Human Nutrition
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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