Progress towards the total synthesis of debromophycolide
| dc.contributor.author | Prigaro, Brett J., author | |
| dc.contributor.author | Wood, John L., advisor | |
| dc.contributor.author | Williams, Robert M., committee member | |
| dc.contributor.author | McNaughton, Brian, committee member | |
| dc.contributor.author | Rappe, Anthony K., committee member | |
| dc.contributor.author | Kurosu, Michio, committee member | |
| dc.date.accessioned | 2007-01-03T05:43:16Z | |
| dc.date.available | 2007-01-03T05:43:16Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | The structure of debromophycolide provides a novel synthetic target that could provide synthetic insight into several other members of the bromophycolide family. Our synthetic efforts toward the total synthesis of debromophycolide are described. The discussion begins with the description of a planned convergent approach to the total synthesis of debromophycolide. Key disconnections dissect the molecule into four distinct fragments that can be joined in multiple ways to incorporate flexibility to the synthesis. Our approach begins with the construction of a benzyl-cyclopentenyl fragment utilizing a transition metal cross-coupling reaction. Then focus shifts towards a functionalized aliphatic fragment, which incorporates a conjugate addition reaction to link the two fragments. Efforts to implement this plan are then described. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | Prigaro_colostate_0053A_10262.pdf | |
| dc.identifier.uri | http://hdl.handle.net/10217/49855 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | bromophycolide | |
| dc.subject | debromophycolide | |
| dc.title | Progress towards the total synthesis of debromophycolide | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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