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Are lines of arrested growth in bone indicative of seasonal metabolic suppression in bears?

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dc.contributor.authorHinrichs, Jason, author
dc.contributor.authorDonahue, Seth, advisor
dc.contributor.authorNorrdin, Robert, committee member
dc.contributor.authorPopat, Ketul, committee member
dc.date.accessioned2016-07-13T14:50:29Z
dc.date.available2016-07-13T14:50:29Z
dc.date.issued2016
dc.description.abstractLarge hibernators such as bears have seasonal metabolic suppression, hibernation (Tøien et al. 2012). During hibernation bear's activity is very low; to the point most other animals would exhibit disuse bone resorption. However bears do not exhibit disuse bone resorption during this time (McGeeLawrence et al. 2008). Are lines of arrested growth (LAGs) in bone indicative of seasonal metabolic suppression in bears? Through the use of toluidine blue stain light microscopy slides and backscattered scanning electron microscopy images (SEM), LAGs were counted and correlated with age. LAGs have a strong correlation with age. This is indicative of LAGs formation once per year, during set hibernation cycles. LAGs are metabolic markers, in bears with set hibernation cycles. These metabolic markers could be used to identify the specific time in which there is metabolic suppression, in bears. This identification could be used in the future to track blood serum and other chemical markers in an attempt to understand bear's natural resistance to disuse bone resorption. Bears ability to not exhibit disuse bone resorption could be biomimetically studied, in an attempt to adapt this protection to humans. Since humans experience disuse osteoporosis (extended bed rest and spaceflight) and osteoporosis (older population specifically women).
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierHinrichs_colostate_0053N_13602.pdf
dc.identifier.urihttp://hdl.handle.net/10217/173554
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcement lines
dc.subjectLAGs
dc.subjectbone
dc.subjectSEM
dc.subjecthibernators
dc.titleAre lines of arrested growth in bone indicative of seasonal metabolic suppression in bears?
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineBioengineering
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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