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The effects of mannose capped lipoarabinomannan on dendritic cell function

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dc.contributor.authorLee, Eric John, author
dc.contributor.authorGonzalez-Juarrero, Mercedes, advisor
dc.contributor.authorSchenkel, Alan, committee member
dc.contributor.authorChen, Chaoping, committee member
dc.date.accessioned2007-01-03T04:54:45Z
dc.date.available2007-01-03T04:54:45Z
dc.date.issued2009
dc.descriptionDepartment Head: Paul J. Laybourn.
dc.description.abstractM. tuberculosis is one of the leading causes of death due to infectious disease in the world. While the majority of people are capable of controlling the initial infection, many progress to a latent stage of disease where the M. tuberculosis bacilli persist for long periods of time within the host. The M. tuberculosis cell wall lipoglycan mannose capped lipoarabinomannan (ManLAM) has been characterized as one of the immunomodulatory factors associated with the bacteria [3-5]. ManLAM interacts with dendritic cells (DCs) via DC-SIGN, mannose receptors and to a lesser extent TLR-2 [6-8]. Thus we set out to examine the effects that ManLAM has on DCs both in vitro and in vivo. ManLAM treatment of bone marrow derived DCs (BMDCs) prevents their phenotypic maturation reduces the expression of MHC class II and CD1d. BMDCs stimulated with ManLAM also exhibit altered phagocytic capacity and the inability to stimulate naïve CD4+ T-cell proliferation.
dc.format.mediummasters theses
dc.identifier2009_spring_Lee.pdf
dc.identifierETDF2009100001CMBO
dc.identifier.urihttp://hdl.handle.net/10217/22102
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relationCatalog record number (MMS ID): 991012230819703361
dc.relationQR82.M8.L45 2009
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleThe effects of mannose capped lipoarabinomannan on dendritic cell function
dc.typeText
dcterms.embargo.expires2009-07-15
dcterms.embargo.terms2009-07-15
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineCell and Molecular Biology
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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