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Novel transcriptomic mechanisms of brain aging

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dc.contributor.authorCavalier, Alyssa Nicole, author
dc.contributor.authorLaRocca, Thomas, advisor
dc.contributor.authorLark, Daniel, committee member
dc.contributor.authorHamilton, Karyn, committee member
dc.contributor.authorWeir, Tiffany, committee member
dc.date.accessioned2024-01-01T11:25:22Z
dc.date.available2024-01-01T11:25:22Z
dc.date.issued2023
dc.description.abstractAs the world ages, the incidence of age-related diseases like dementia is expected to increase. Brain aging is characterized by declines in cognitive function that may develop into mild cognitive impairment, which increases the risk for dementia. In fact, age is the primary risk factor for late-onset Alzheimer's disease, which is the most common age-related dementia. The adverse cellular and molecular processes that underlie cognitive decline with aging in the brain are known collectively as the "hallmarks of brain aging." Advances in next-generation sequencing (e.g., transcriptomics/RNA-seq) have made it possible to investigate age- and disease-related changes in the brain at the broad gene expression level, and to identify potential therapeutic targets. With the support of my committee and mentoring team, I completed three studies using transcriptomics that characterize novel mechanisms that underlie brain aging. My findings include: (1) doxorubicin chemotherapy accelerates brain aging at the gene expression level, (2) apigenin nutraceutical supplementation targets age-related inflammation in the brain and rescues cognitive impairment in old mice, and (3) epigenetic dysregulation of transposable elements (remnants of viral infection in the genome) with aging contributes to age-related inflammation in Alzheimer's disease. Together, my work provides insight into transcripts and cellular/molecular pathways that are modifiable and may be therapeutic targets to delay or prevent consequences of brain aging.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierCavalier_colostate_0053A_18118.pdf
dc.identifier.urihttps://hdl.handle.net/10217/237454
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectAlzheimer's disease
dc.subjectRNA-seq
dc.subjectaging
dc.subjecttranscriptomics
dc.subjectbrain aging
dc.titleNovel transcriptomic mechanisms of brain aging
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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