Repository logo
 

Development of a hyaluronan-polyethylene copolymer for use in articular cartilage repair

Simple item page
dc.contributor.authorOldinski, Rachael, author
dc.contributor.authorJames, Susan P., advisor
dc.date.accessioned2024-03-13T20:12:28Z
dc.date.available2024-03-13T20:12:28Z
dc.date.issued2009
dc.description.abstractArticular cartilage is the connective tissue which covers the ends of long bones, providing a lubricious, hydrodynamic surface for articulation and energy dissipation. Articular cartilage has a limited ability to repair itself; once the native tissue has become damaged, either from injury or disease (e.g., arthritis), it is irreversible and the tissue will degrade with time resulting in joint pain. The goal of this research was to develop a permanent (i.e., non biodegradable/bioerodible) bioactive material and assess its applicability for articular cartilage repair and/or replacement. Utilizing two constituents, polyethylene (the 'gold standard' bearing material for total joint replacements) and hyaluronan (HA, a native component of articular cartilage), a hyaluronan-polyethylene graft copolymer (HA-co-HDPE) was developed. The novel HA- co-HDPE material was successfully synthesized using an interfacial polymerization reaction in a non-aqueous environment. Although the material has limited melt-processability, it is more processable than HA and was successfully compression molded into samples for physical, mechanical and in vitro biological characterization (e.g., swell ratio, dynamic mechanical analysis). HA-co-HDPE exploits the strength, rigidity and melt-processability associated with HDPE, and achieves increased osteogenic potential by incorporating the highly hydrophilic biopolymer HA. In conclusion, the swelling, mechanical and degradation properties of the copolymer can be custom-optimized for biomedical applications by tailoring chemical or physical crosslinking strategies and varying the amount and molecular weights of HA and HDPE incorporated into the copolymer.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierETDF_Oldinski_2009_3374637.pdf
dc.identifier.urihttps://hdl.handle.net/10217/237896
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.licensePer the terms of a contractual agreement, all use of this item is limited to the non-commercial use of Colorado State University and its authorized users.
dc.subjectarticular cartilage
dc.subjectbiomaterials
dc.subjecthyaluronan-polyethylene copolymer
dc.subjectpolymer chemistry
dc.subjectpolymer engineering
dc.subjectpolymer science
dc.subjectbiomedical engineering
dc.subjectmechanical engineering
dc.subjectmaterials science
dc.titleDevelopment of a hyaluronan-polyethylene copolymer for use in articular cartilage repair
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineMechanical Engineering
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ETDF_Oldinski_2009_3374637.pdf
Size:
3.91 MB
Format:
Adobe Portable Document Format
Download

Collections

2000-2019
Theses and Dissertations