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Respiratory morbidity in susceptible populations: the role of joint exposure to multiple environmental chemicals and pollutants

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dc.contributor.authorBenka-Coker, Wande, author
dc.contributor.authorMagzamen, Sheryl, advisor
dc.contributor.authorPeel, Jennifer, committee member
dc.contributor.authorWilson, Ander, committee member
dc.contributor.authorAnderson, Brooke, committee member
dc.date.accessioned2019-06-14T17:06:39Z
dc.date.available2021-06-10T17:05:25Z
dc.date.issued2019
dc.description.abstractExposure to ambient pollution from environmental chemicals and pollutants has been associated with a range of adverse respiratory outcomes; susceptible populations are disproportionately affected. Children with asthma are particularly at risk for adverse respiratory effects of environmental agents. The recent increase in US and worldwide pediatric asthma prevalence has encouraged new lines of inquiry focusing on environmental factors, rather than genetic factors, as the main etiologic agent in asthma-related morbidity; the complex relationship between individuals and their environment requires improved characterization and quantification.
dc.description.abstractThe study of potential joint effects from multiple environmental chemical stressors is particularly relevant for chronic diseases with strong environmental antecedents, including asthma. As children with asthma tend to have spatially and temporally heterogeneous exposure to multiple domains of environmental chemicals determined by regional characteristics, study approaches with an understanding of the complexities of exposure (i.e. exposure data that are high dimensional and strongly correlated) of the health impact of multiple pollutants are required.
dc.description.abstractIn this dissertation, we sought to evaluate the association between multipollutant exposures to ambient environmental chemicals and pollutants (ECP) and respiratory morbidity in uniquely exposed populations. By implementing health risk-based multipollutant epidemiologic approaches, we targeted potential synergistic effects within multiple domains of ambient ECP, with specific attention to criteria air pollutants and agricultural pesticides.
dc.description.abstractChapter 1 describes background information relevant to the dissertation while providing context for the multipollutant approaches and highlighting the specific objectives; Chapters 2 – 4 summarize methodology, study findings and aim-specific discussion; and the final chapter provides a discussion of overall findings, strengths, limitations, and suggestions for future research.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierBenkaCoker_colostate_0053A_15419.pdf
dc.identifier.urihttps://hdl.handle.net/10217/195374
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleRespiratory morbidity in susceptible populations: the role of joint exposure to multiple environmental chemicals and pollutants
dc.typeText
dcterms.embargo.expires2021-06-10
dcterms.embargo.terms2021-06-10
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineEnvironmental and Radiological Health Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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