Investigation of the extraction of stable ⁴⁵Sc and carrier free ⁴⁴Sc for theranostic applications
Date
2022
Authors
Brown, Morgan L., author
Sudowe, Ralf, advisor
Brandl, Alexander, committee member
Zadrozny, Joseph, committee member
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Abstract
Scandium is an element of major interest when it comes to theranostic applications. There are mainly two isotopes of scandium utilized in medical applications, Sc-44 and Sc-47. Sc-44 is a positron emitter and is used for imaging, while Sc-47 is utilized as a beta emitter for targeting tumors. Together, the pair make up a theranostic agent. This research mainly focuses on Sc-44. To utilize the isotope after production, it must first be separated and purified from target material, in this case titanium. One of the quickest and most efficient way to separate radioisotopes, especially for medical purposes, is extraction chromatography. The goal of this research is to understand and possibly improve the separation of scandium from titanium by employing a variety of different chromatographic resins in a fast manner. Previous studies in the literature yielded data from several groups that examined the uptake of scandium and titanium on an extraction chromatographic resin based on a tetraoctyl diglycolamide, DGA. These groups employed either stable or radioactive scandium for their experiments. While the uptake of titanium was consistent between the studies, all groups have reported different values for the uptake of scandium. The aim of this part of the work is to compare both the uptake of stable and radioactive scandium to further elucidate the discrepancies between the studies reported in the literature. Radioactive Sc-44 for tracer studies will be obtained by "milking" a Ti-44 generator in regular intervals. Both stable and radioactive results obtained in this research will be compared.
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Subject
scandium
theranostic
separations
radiochemistry