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Evaluating the efficacy of a Mycobacterium bovis vaccine in feral swine

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dc.contributor.authorTopliff-Yee, Elizabeth Kathrine, author
dc.contributor.authorHolt, Timothy, advisor
dc.contributor.authorNol, Pauline, committee member
dc.contributor.authorBowen, Richard, committee member
dc.date.accessioned2018-01-17T16:45:30Z
dc.date.available2018-01-17T16:45:30Z
dc.date.issued2017
dc.description.abstractBovine tuberculosis (bTB) is a globally significant zoonotic disease caused primarily by Mycobacterium bovis (M. bovis) transmission between wildlife, domestic livestock, and humans. Unfortunately in wildlife reservoirs of bTB, disease rates are increasing worldwide due to ecological dynamics and challenges in wildlife management. Despite effective, long-standing M. bovis eradication programs in the US, expanding wildlife reservoir habitat and importation of people, animals, and products from the Mexican dairy industry have become sources of zoonotic bTB infection. Currently, no tuberculosis vaccine is labeled for use in animals, although a vaccine could provide a new tool in preventing bTB in wildlife and domestic livestock. Bacille Calmette-Guerin (BCG), a live, attenuated M. bovis strain vaccine used for tuberculosis prevention in humans has been variably effective in reducing bTB development in studies on various species. We hypothesize that Texas-origin feral swine vaccinated orally with either modified-live BCG or inactivated M. bovis vaccine will have fewer, less severe lesions than non-vaccinated feral swine after virulent M. bovis challenge. In this study we test this hypothesis along with the immunologic response to vaccination and infection by measuring antibody levels in vaccinated and unvaccinated swine. Our results demonstrate that vaccination with BCG or inactivated strains of M. bovis do not confer protection against infectious challenge with a virulent Michigan strain of M. bovis.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierTopliffYee_colostate_0053N_14434.pdf
dc.identifier.urihttps://hdl.handle.net/10217/185629
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectbovine
dc.subjectswine
dc.subjectvaccine
dc.subjecttuberculosis
dc.subject.lcshMycobacterium
dc.subject.lcshBCG
dc.titleEvaluating the efficacy of a Mycobacterium bovis vaccine in feral swine
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineClinical Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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