Sc-26196, a delta-6 desaturase inhibitor, normalizes glucose tolerance in ob/ob mice
| dc.contributor.author | Routh, Melissa Anne, author | |
| dc.contributor.author | Chicco, Adam J., advisor | |
| dc.contributor.author | Bouma, Gerrit, committee member | |
| dc.contributor.author | Frye, Melinda, committee member | |
| dc.contributor.author | Paul, Laybourn, committee member | |
| dc.date.accessioned | 2007-01-03T08:07:05Z | |
| dc.date.available | 2007-01-03T08:07:05Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | The incidence of diabetes has reached epidemic levels worldwide, and while researchers know more about the phenomenon than ever, an effective treatment still remains elusive. Recently, chronic low-grade inflammation has been shown to play a key role in insulin resistance and diabetes. The purpose of this study was to demonstrate a role for the delta-6 desaturase (D6D) in diabetes, and furthermore to elucidate the potential mechanism by which inhibition of D6D by sc-26196 treatment could restore glucose tolerance in obese insulin resistant ob/ob mice. Treatment of 4-month-old male ob/ob mice with the selective D6D inhibitor sc-26196 (SC, 100 mg/kg/d for 4 weeks) improved response to an acute glucose challenge (1 mg/g BW i.p.), as indicated by lower peak (146% vs. 219% of fasting) and final (85% vs. 180% of fasting 2 hours-post bolus) blood glucose levels versus untreated ob/ob mice (p<0.01). Increased hepatic macrophage infiltration in addition to increased phosphorylation of JNK proteins and inhibitory IRS phosphorylation in untreated ob mice was attenuated by sc-26196 treatment, which suggests that D6D inhibition improves glucose tolerance by decreasing inflammation and restoring insulin signaling by way of the IRS/PI3K pathway. This study demonstrates the effectiveness of sc-26196 treatment for glucose intolerance in ob/ob mice and results warrant future studies for use of sc-26196 in the clinical treatment of insulin resistance and diabetes. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Routh_colostate_0053N_11085.pdf | |
| dc.identifier | ETDF2012500093CMBO | |
| dc.identifier.uri | http://hdl.handle.net/10217/66674 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | Sc-26196, a delta-6 desaturase inhibitor, normalizes glucose tolerance in ob/ob mice | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Cell and Molecular Biology | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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