Synthetic studies on (-) lemonomycin: construction of the tetracyclic core
| dc.contributor.author | Jiménez-Somarribas, Alberto, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.contributor.author | Wood, John L., committee member | |
| dc.contributor.author | Shi, Yian, committee member | |
| dc.contributor.author | Ladanyi, Branka M., committee member | |
| dc.contributor.author | Crick, Dean C., committee member | |
| dc.date.accessioned | 2007-01-03T06:08:57Z | |
| dc.date.available | 2007-01-03T06:08:57Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Documented herein are efforts towards the asymmetric total synthesis of (-)-lemonomycin, a member of the tetrahydroisoquinoline antitumor antibiotics family of natural products. We describe a concise route for the assembly of the tetracyclic core of this molecule, which involves a Pictet-Spengler reaction for the construction of the tetrahydroisoquinoline fragment and an azomethine ylide [3+2] dipolar cycloaddition for the construction of the diazabicyclo[3.2.1]octane ring system. The above-described synthetic efforts, while not totally successful, provide the basis for the future completion of the total synthesis of this natural product and other related compounds. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | Jimenez_colostate_0053A_11991.pdf | |
| dc.identifier | ETDF2013500353CHEM | |
| dc.identifier.uri | http://hdl.handle.net/10217/80986 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | [3+2] dipolar cycloaddition | |
| dc.subject | Pictet-Spengler reaction | |
| dc.subject | Lemonomycin | |
| dc.subject | asymmetric synthesis | |
| dc.title | Synthetic studies on (-) lemonomycin: construction of the tetracyclic core | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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