Development of an ovine cardiac model for the modified Blalock-Thomas-Taussig shunt
| dc.contributor.author | Chu, Margaret Lucinda, author | |
| dc.contributor.author | Monnet, Eric, advisor | |
| dc.contributor.author | Marvel, Sarah, committee member | |
| dc.contributor.author | Randall, Elissa, committee member | |
| dc.date.accessioned | 2023-06-01T17:27:06Z | |
| dc.date.available | 2023-06-01T17:27:06Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | This pilot study aimed to better describe the ovine thoracic vascular anatomy, to develop a model for placement of a modified Blalock-Thomas-Taussig (BT) shunt in sheep, and to evaluate whether hyaluronan-treated grafts would have decreased thrombosis and adherence compared to traditional polytetrafluoroethylene (PTFE) grafts. Ovine thoracic vasculature follows the pattern of a bovine aortic arch and branching of arterial vascular does not occur until the thoracic inlet. A prominent left azygos vein and ligamentum arteriosum are also present. Placement of a modified BT-shunt was possible in sheep and did appear to lead to some long-term changes in cardiac values. Hyaluronan-treated shunts were subjectively less adherent with incomplete thrombosis occurring in the subjects. Further research is needed to better evaluate the latter two aims of this project. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Chu_colostate_0053N_17646.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/236577 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2020- | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | cardiac energetics | |
| dc.subject | ovine model | |
| dc.subject | congenital heart disease | |
| dc.subject | Blalock Thomas Taussig shunt | |
| dc.title | Development of an ovine cardiac model for the modified Blalock-Thomas-Taussig shunt | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Clinical Sciences | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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