Repository logo
 

Temperature increase measurements of multiple 10 ms pulses of 2.01 μm laser light incident on ex-vivo rabbit corneas

Simple item page
dc.contributor.authorKelly, Edward, author
dc.contributor.authorJohnson, Thomas, advisor
dc.contributor.authorBrandl, Alexander, committee member
dc.contributor.authorWoody, Robert, committee member
dc.date.accessioned2007-01-03T05:48:02Z
dc.date.available2007-01-03T05:48:02Z
dc.date.issued2011
dc.description.abstractCurrent laser safety standards for multiple-pulse lasers are based primarily on modeling and the results of single-pulse studies. Previous thermal effects studies have focused on histological and visible endpoints, with only a few studies examining the actual temperatures achieved. The goal of this research was to probe the actual temperature profile produced by 2.01-micron laser pulses in the cornea. In this study the corneal temperature rise from multiple 2.01-micron Tm:YAG laser pulses was investigated using ex-vivo rabbit eyes. An infrared thermal camera employing microbolometer detectors captured surface temperature rises resulting from laser pulses. Thermal measurements were taken with single 10-ms pulses as well as two-, three-, and four-pulse sequences while holding the total energy delivered constant for the two- through four-pulse train measurements. An average temperature increase of 8.3 degrees C was observed with the single pulse at 2.8 J/cm2/pulse irradiance. For two pulses, an average temperature increase of 10.0 degrees C was observed for 2.7 J/cm2/pulse irradiance. For three pulses, an average temperature increase of 5.8 degrees C was observed for 1.9 J/cm2/pulse irradiance. For four pulses, an average temperature increase of 4.4 degrees C was observed for 1.5 J/cm2/pulse irradiance. A comparison of the data to temperatures required for denaturing proteins and the current laser safety guidelines is presented. It appears that the MPE may be overly conservative by a factor of at least 15. It is recommended that the 2.01-micron laser MPE be investigated to determine if a revision of the standard is warranted.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierKelly_colostate_0053N_10286.pdf
dc.identifier.urihttp://hdl.handle.net/10217/51878
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subject2.01 micron laser pulses in the cornea
dc.subjectlaser safety standards for multiple pulse lasers
dc.subjectlaser safety guidelines
dc.subjectcorneal temperature rise
dc.titleTemperature increase measurements of multiple 10 ms pulses of 2.01 μm laser light incident on ex-vivo rabbit corneas
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineEnvironmental and Radiological Health Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kelly_colostate_0053N_10286.pdf
Size:
1.67 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

2000-2019
Theses and Dissertations