Understanding and leveraging mechanical forces in haemostasis
| dc.contributor.author | Macleod Briongos, Iain, author | |
| dc.contributor.author | Bark, David, advisor | |
| dc.contributor.author | Olver, Christine, committee member | |
| dc.contributor.author | Popat, Ketul, committee member | |
| dc.contributor.author | Henry, Charles, committee member | |
| dc.date.accessioned | 2024-01-01T11:25:19Z | |
| dc.date.available | 2024-01-01T11:25:19Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Cardiovascular disease accounts for one third of deaths worldwide, of which over 75% are in low- and middle-income countries. Platelets and von Willebrand Factor play a central role in haemostasis and in cardiovascular diseases, being involved in both excess clotting that causes heart attacks and strokes, and excess bleeding. Herein, we outline a method for leveraging paper microfluidics with the aim of developing a WHO ASSURED criteria compliant point-of-care device for the diagnosis of von Willebrand Disease, as well as work to increase the understanding of mechanical force generation by platelets through Traction Force Microscopy. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | MacleodBriongos_colostate_0053A_18086.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/237436 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2020- | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | microfluidics | |
| dc.subject | TFM | |
| dc.subject | VWF | |
| dc.subject | platelets | |
| dc.subject | biomechanics | |
| dc.subject | VWD | |
| dc.title | Understanding and leveraging mechanical forces in haemostasis | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Biomedical Engineering | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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