The development of N-heterocyclic carbenes for application in the intermolecular stetter reaction
| dc.contributor.author | Rhorer, Timothy Benjamin, author | |
| dc.contributor.author | Rovis, Tomislav, advisor | |
| dc.contributor.author | Ferreria, Eric M., committee member | |
| dc.contributor.author | Inamine, Julia, committee member | |
| dc.date.accessioned | 2007-01-03T08:10:25Z | |
| dc.date.available | 2007-01-03T08:10:25Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | An N-heterocyclic carbene scaffold has been developed containing a protected oxygen moiety in the backbone. The oxygen provides a similar electronic effect known to fluorinated analogues, and also has the potential to be modulated via substitution. This substitution introduces steric differentiation distil to the reaction site and electronic manipulation of the calculated catalyst substrate interaction. A short synthesis has been designed with an intermediate that allows for divergent manipulation of the oxygen substituent. The resultant carbenes catalyze the intermolecular Stetter reaction with similar yields and enantioselectivities to those observed with previously designed catalysts with only fluorine substitution. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Rhorer_colostate_0053N_11169.pdf | |
| dc.identifier | ETDF2012500180CHEM | |
| dc.identifier.uri | http://hdl.handle.net/10217/67900 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject | carbene | |
| dc.title | The development of N-heterocyclic carbenes for application in the intermolecular stetter reaction | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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