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Omega-3 fatty acids, lipoprotein-associated phospholipase A₂ and oxidized LDL in glucose sensitive and glucose intolerant males and females

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dc.contributor.authorDhara, Jerusa, author
dc.contributor.authorNelson-Ceschin, Tracy L., advisor
dc.contributor.authorBizeau, Michael, committee member
dc.contributor.authorHickey, Matthew S., committee member
dc.date.accessioned2007-01-03T04:40:54Z
dc.date.available2007-01-03T04:40:54Z
dc.date.issued2010
dc.descriptionDepartment Head: Richard Gay Israel.
dc.description.abstractLp-PLA2 is a novel inflammatory marker that has been proposed as an independent risk marker for cardiovascular disease. Lp-PLA2 in circulation is principally bound to low-density lipoprotein cholesterol (LDL-C) in humans and the substrate for the enzyme is provided by the oxidized phospholipid component of LDL-C. In the present study, plasma levels of Lp-PLA2 concentration, activity and plasma levels of oxidized LDL were measured in fifty-nine weight stable adults, mean age 61 years, at baseline and following an 8-week supplementation of ALA, EPA+DHA or control (olive oil). Additionally, glucose, LDL-C, HDL-C, triglycerides and insulin levels were measured at baseline and following the intervention. Fasting blood glucose was measured for the purpose of assessing changes between glucose intolerant and glucose sensitive individuals. Results showed that there was no significant change in the concentration or activity of Lp-PLA2 either in low ox-LDL group or high ox-LDL group after ALA or EPA/DHA supplementation in diet. No particular trend was observed, however, a slight decrease in Lp-PLA2 concentration in all the three groups (CON, ALA, and EPA/DHA) was seen in higher ox-LDL group. But Lp-PLA2 activity only decreased in ALA group (Baseline=163.42 mmol/min/mL + 27.29; week 8 =143.25 mmol/min/mL+14.52) in high ox-LDL group. A minor increase in Lp-PLA2 concentration in the control group (baseline= 206 ng/mL +62.29; week 8= 215.01 ng/mL+73.26) in low ox-LDL group and a slight decrease in Lp-PLA2 activity in control group was observed (baseline= 137.97 mmol/min/mL+ 27.50; week 8= 133.92 mmol/min/mL+28.56). There were no significant changes in fasting plasma ox-LDL after the diet supplementation in any of the groups, but a decreasing trend in LDL-C was observed. In glucose sensitive subjects, a positive correlation between Lp-PLA2 activity and ox-LDL is seen at p<0.01 level. The results of this study also do not represent a baseline significant relation between Lp-PLA2 concentration and activity and ox-LDL in glucose intolerant subjects. The results support the view that Lp-PLA2 is associated with ox-LDL, but do not provide any evidence that omega-3 fats mediate the inflammatory process via Lp-PLA2 or ox-LDL.
dc.format.mediummasters theses
dc.identifier2010_Spring_Dhara_Jerusa.pdf
dc.identifierETDF2010100004HAES
dc.identifierQP752.O44 D45 2010
dc.identifier.urihttp://hdl.handle.net/10217/38352
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleOmega-3 fatty acids, lipoprotein-associated phospholipase A₂ and oxidized LDL in glucose sensitive and glucose intolerant males and females
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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