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Infectious disease, age, and environmental contaminants as neurotoxicants that modulate glia and contribute to neurodegenerative pathology

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dc.contributor.authorLatham, Amanda Shellee, author
dc.contributor.authorMoreno, Julie A., advisor
dc.contributor.authorBasaraba, Randall J., advisor
dc.contributor.authorTjalkens, Ronald B., committee member
dc.contributor.authorSantangelo, Kelly S., committee member
dc.contributor.authorElf, Jessica, committee member
dc.date.accessioned2024-05-27T10:32:55Z
dc.date.available2025-05-20
dc.date.issued2024
dc.description.abstractNeurodegenerative disease cases are expected to double over the next twenty years. These diseases, which include Alzheimer's Disease (AD) and Parkinson's Disease (PD), are incurable with a largely unknown etiology. It is acknowledged within the field that age is the greatest risk factor for neurodegenerative disease, and that genetics and environmental factors, such as neurotoxicants and infectious agents, likely play a role. Despite this knowledge, it is not entirely understood why select individuals are pushed into a state of disease, while others progress into a state of normal brain aging. This is further complicated by the shared neuropathology between brain aging and neurodegenerative disease, which includes blood-brain barrier (BBB) modulation, gliosis, misfolded protein accumulation, and loss of function or degradation of neurons. To address these gaps in our understanding, the studies herein provide valuable insight as to how infectious disease, specifically through infection with Mycobacterium tuberculosis, contributes to the progression of neuropathology, evaluates an alternative model of brain aging that better recapitulates human disease, and provides mechanistic understanding of the neuroprotective and neurotoxic roles of glia in disease. Altogether, these data elucidate the etiology and mechanisms that drive neurodegenerative disease, as well as possible therapeutic avenues that may bring us one step closer to a cure.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierLatham_colostate_0053A_18322.pdf
dc.identifier.urihttps://hdl.handle.net/10217/238517
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.accessEmbargo expires: 05/20/2025.
dc.subjectglia
dc.subjectneurotoxicity
dc.subjecttuberculosis
dc.subjectneuroinflammation
dc.subjectaging
dc.subjectParkinson's disease
dc.titleInfectious disease, age, and environmental contaminants as neurotoxicants that modulate glia and contribute to neurodegenerative pathology
dc.typeText
dcterms.embargo.expires2025-05-20
dcterms.embargo.terms2025-05-20
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineEnvironmental and Radiological Health Sciences
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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