The synthesis of the pentacyclic carbon framework of the PF1270 family of natural products
| dc.contributor.author | Sanchez, Michelle A., author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.contributor.author | Kennan, Alan, committee member | |
| dc.contributor.author | Rovis, Tomislav, committee member | |
| dc.contributor.author | Levinger, Nancy, committee member | |
| dc.contributor.author | Crick, Dean, committee member | |
| dc.date.accessioned | 2007-01-03T06:33:11Z | |
| dc.date.available | 2007-01-03T06:33:11Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | The PF1270 family of natural products contains novel indole alkaloids that display interesting biological activity; the synthesis of these natural products and their analogs could lead to the discovery of novel therapeutics. Discussed herein is the synthesis of the complete pentacyclic carbon framework of the PF1270s, accomplished through a key intermolecular Diels-Alder reaction. Other highlights of the synthesis include an acid catalyzed opening lactim ether at a late stage, and a particularly difficult decarboxylation promoted by diphenylphosphoryl azide. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | Sanchez_colostate_0053A_12452.pdf | |
| dc.identifier.uri | http://hdl.handle.net/10217/83811 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | The synthesis of the pentacyclic carbon framework of the PF1270 family of natural products | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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