Studies towards the total synthesis of spiroquinazoline
| dc.contributor.author | Chen, Siyuan, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.date.accessioned | 2022-11-28T17:46:44Z | |
| dc.date.available | 2022-11-28T17:46:44Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Presented herein is the synthesis of a key intermediate in the total synthesis of spiroquinazoline. By using N-Boc-serine as starting material, an efficient methodology has been developed to synthesize two types of δ,γ-unsaturated-α-amino acids bearing substitution at either the δ- or γ-position. After this, a novel SN2' reaction which introduces two quaternary centers has been developed. The quinazolinone core of the molecular has been constructed. The progress we made in those key steps paves the way to the first total synthesis of spiroquinazoline. | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier.uri | https://hdl.handle.net/10217/235850 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991009481519703361 | |
| dc.relation | QD401.C52 2007 | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject.lcsh | Quinazoline -- Synthesis | |
| dc.subject.lcsh | Organic compounds -- Synthesis -- Methodology | |
| dc.title | Studies towards the total synthesis of spiroquinazoline | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ETDF_2007Su_Chen_Siyuan_DIP.pdf
- Size:
- 16.74 MB
- Format:
- Adobe Portable Document Format