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Peripheral blood flow regulation in persons with multiple sclerosis

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dc.contributor.authorKetelhut, Nathaniel B., author
dc.contributor.authorFling, Brett W., advisor
dc.contributor.authorHickey, Matthew S., committee member
dc.contributor.authorChicco, Adam J., committee member
dc.contributor.authorMyers, Brent, committee member
dc.date.accessioned2022-01-07T11:30:38Z
dc.date.available2024-01-06T11:30:38Z
dc.date.issued2021
dc.description.abstractMultiple sclerosis (MS) is an inflammatory, degenerative disease of the central nervous system that is believed to be autoimmune in nature. The disease affects approximately one million people in the United States and results in a wide variety of symptoms including impaired physical function, reduced exercise capacity, and increased fatigability. Although considerable effort has been invested in improving our understanding of the neuromuscular contributions to these symptoms, no studies have investigated whether cardiovascular autonomic dysfunction compromises skeletal muscle blood flow in persons with MS (PwMS). Indeed, approximately 50% of PwMS have an abnormal response to tests of cardiovascular autonomic function, and skeletal muscle blood flow is positively associated with exercise capacity. Thus, the overall goal of this dissertation was to determine whether PwMS have impaired skeletal muscle blood flow responses to exercise relative to age- and sex-matched healthy controls. The primary findings are that 1) the local control of skeletal muscle blood flow during exercise is intact in PwMS, 2) skeletal muscle blood flow is likely reduced during exercise that engages the autonomic nervous system in MS, which may be due to increased α-adrenergic mediated vascular tone, and 3) that PwMS may experience hypersensitivity to α-adrenergic signaling as evidenced by levels of systemic vascular resistance relative to plasma concentrations of norepinephrine. Together, these studies indicate that compromised skeletal muscle blood flow during exercise may contribute to reduced exercise capacity and increased fatigability in PwMS.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierKetelhut_colostate_0053A_16889.pdf
dc.identifier.urihttps://hdl.handle.net/10217/234278
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcardiovascular
dc.subjectfatigue
dc.subjectneurological disorders
dc.subjectexercise capacity
dc.subjectblood flow
dc.subjectmultiple sclerosis
dc.titlePeripheral blood flow regulation in persons with multiple sclerosis
dc.typeText
dcterms.embargo.expires2024-01-06
dcterms.embargo.terms2024-01-06
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineHealth and Exercise Science
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

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