Repository logo
 

The effects of moderate exercise on measures of postprandial lipemia

Simple item page
dc.contributor.authorCox-York, Kimberly Ann, author
dc.contributor.authorHorton, Tracy J., advisor
dc.contributor.authorPagliassotti, Michael, advisor
dc.date.accessioned2024-03-13T19:26:10Z
dc.date.available2024-03-13T19:26:10Z
dc.date.issued2009
dc.description.abstractBackground. Elevated triglycerides (TG) and small lipid particle size are risk factors for cardiovascular disease (CVD), which are typically assessed after an overnight fast. Most individuals spend the day in the postprandial (PP) state, however, which might be more reflective of CVD risk. A single exercise bout has been shown to decrease PP TGs in response to a single, high-fat meal. The current study assessed the effect of a single bout of morning exercise on PP lipids over an entire day with 3 mixed meals of a typical macronutrient composition (34% fat, 15% protein, 51% CHO). Methods. 26 normal weight (NW) subjects and 18 subjects with metabolic syndrome (MetS) were studied. After an overnight fast, subjects exercised (treadmill walking, 60%VO2peak) or rested for 60 min then consumed breakfast, lunch, and dinner, contributing 25%, 35% and 40% of daily energy intake respectively. Fasting blood samples were collected before exercise or rest and continued throughout the day and were analyzed for PP lipids, glucose and insulin. A subset of the plasma samples were separated into triglyceride-rich lipoprotein (TRL) subfractions in which TG and cholesterol were measured. Apolipoprotein (apo) B-100 and B-48 proteins were measured in the medium-sized subfraction (TRL2) to assess particle origin, size and composition. Postprandial responses were analyzed via ANOVA (SPSS 16.0). Results. Overall, exercise had no effect on PPTG. With exercise, total apoB IAUC decreased 20% in the whole group, and total cholesterol IAUC decreased 30% in the NW group. MetS subjects maintained significantly higher TG than NW subjects over the day (p<0.001). PPTG in MetS women declined mid-day, and remained low for the rest of the study day. In MetS men, however, PPTG rose consistently from breakfast, and then leveled out post-lunch and remained high. TRL particle size (TG:apoB ratio) was 30% lower in MetS women than MetS men. TRL2 apoB-100 and B-48 were twice as high in MetS as in NW subjects, resulting in significantly smaller particles in the MetS group (p=0.01). Conclusions. Although exercise did not have a significant effect on PPTG, there were other potentially cardio-protective effects on apoB and cholesterol levels.
dc.format.mediumborn digital
dc.format.mediumdoctoral dissertations
dc.identifierETDF_Cox-York_2009_3374639.pdf
dc.identifier.urihttps://hdl.handle.net/10217/237664
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.rights.licensePer the terms of a contractual agreement, all use of this item is limited to the non-commercial use of Colorado State University and its authorized users.
dc.subjectapolipoprotein B
dc.subjectcardiovascular disease
dc.subjectphysical exercise
dc.subjectpostprandial lipemia
dc.subjecttriglycerides
dc.subjectnutrition
dc.subjectkinesiology
dc.subjectphysiology
dc.titleThe effects of moderate exercise on measures of postprandial lipemia
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineFood Science and Human Nutrition
thesis.degree.grantorColorado State University
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy (Ph.D.)

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ETDF_Cox-York_2009_3374639.pdf
Size:
1.65 MB
Format:
Adobe Portable Document Format
Download

Collections

2000-2019
Theses and Dissertations