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Preparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications

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dc.contributor.authorSun, Yu, author
dc.contributor.authorLi, Yan Vivian, advisor
dc.contributor.authorBailey, Travis, committee member
dc.contributor.authorWang, Zhijie, committee member
dc.date.accessioned2019-09-10T14:36:41Z
dc.date.available2019-09-10T14:36:41Z
dc.date.issued2019
dc.description.abstractWound treatment has always been a popular topic around the world. Since the emergence of nanotechnology, the development and design of novel wound dressing materials have been dramatically improved. The ues of nanoparticles encapsulated with antibiotics to deliver drugs has been shown to be a potentially effective approach to control bacterial infections at a wound position. Recently, biodegradable and biocompatible polymers have drawn lots of attention for the manufacture of drug-loaded nanoparticles in the pharmaceutical industry. In this work, poly-lactic-co-glycolic acid (PLGA) was used in nanoparticle synthesis due to its biodegradability, biocompatibility, and nontoxicity. For this work, gentamicin was loaded into the PLGA nanoparticles as an antibiotic because it is a broad-spectrum antibiotic effective in wound treatments. PLGA nanoparticles were prepared while gentamicin was loaded in the nanoparticles via a double emulsion evaporation method. Poly vinyl alcohol (PVA) was a surfactant that was an important factor in determining the most probable nanoparticle size and morphology. When the PVA concentrations were 9% and 12%, the nanoparticles demonstrated a spherical structure with a porous surface. The porous surface of a nanoparticle was promising for the purpose of releasing encapsulated antibiotics. Another important factor in determining the formation of nanoparticles was the PLGA concentration. Poly lactic-co-glycolic acid (PLGA) was the main material affecting PLGA nanoparticles' properties. PLGA nanoparticles would have various release profiles, morphology, and size distribution with different PLGA concentrations. The results suggested that different PLGA concentrations can endow PLGA nanoparticles with various properties which can lead to different applications of PLGA nanoparticles.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierSun_colostate_0053N_15665.pdf
dc.identifier.urihttps://hdl.handle.net/10217/197434
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectparticle morphology and size
dc.subjectrelease profile study
dc.subjectPLGA nanoparticles
dc.subjectdrug delivery
dc.titlePreparation and characterization of poly lactic-co-glycolic nanoparticles encapsulated with gentamicin for drug delivery applications
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineAdvanced Materials Discovery
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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