Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability
| dc.contributor.author | Williams, Natasha N. Bondareva, author | |
| dc.contributor.author | Bell, Christopher, advisor | |
| dc.contributor.author | Weir, Tiffany, committee member | |
| dc.contributor.author | LaRocca, Tom, committee member | |
| dc.date.accessioned | 2022-01-07T11:28:43Z | |
| dc.date.available | 2022-01-07T11:28:43Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are conflicting. Differences between CBD preparations and bioavailability may contribute to these discrepancies. Further, an influence of body composition on CBD bioavailability is feasible, but currently undocumented. The aims of this study were to: (1) compare the pharmacokinetics of five oral CBD preparations over 4 hours; (2) examine the relationship between body composition and CBD pharmacokinetics; and, (3) explore the influence of CBD on heart rate variability. In total, five preparations of CBD, standardized to 30 mg, were administered orally to 15 healthy men and women (21–62 years) in a randomized, crossover design. Prior to and 60 min following CBD ingestion, heart rate variability was determined. Body composition was assessed using dual energy X-ray absorptiometry. Peak circulating CBD concentration, time to peak concentration, and area under the curve was superior in a preparation comprising 5% CBD concentration liquid. Fat free mass was a significant predictor (R2 = 0.365, p = 0.017) of time to peak concentration for this preparation. Several heart rate variability parameters, including peak frequency of the high frequency band, were favorably, but modestly modified following CBD ingestion. These data confirm an influence of CBD preparation and body composition on CBD bioavailability, and suggest that acute CBD ingestion may have a modest influence on autonomic regulation of heart rate. | |
| dc.format.medium | born digital | |
| dc.format.medium | masters theses | |
| dc.identifier | Williams_colostate_0053N_16885.pdf | |
| dc.identifier.uri | https://hdl.handle.net/10217/234171 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2020- | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Health and Exercise Science | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
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