Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids
| dc.contributor.author | Kosogof, Christi, author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.date.accessioned | 2022-11-28T17:46:49Z | |
| dc.date.available | 2022-11-28T17:46:49Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. Unfortunately, the high levels of hepatotoxicity induced by these compounds negates their effectiveness as antitumor agents. Modification of the chemical structure of the pyrrolizidine core could yield compounds with potent antitumor activity and reduced hepatotoxicity. The synthesis of a class of potential pyrrolizidine progenitors developed from monocrotaline is discussed. The synthesis of a potential water soluble photolabile protecting group is also described. In addition, the biological evaluation of the synthesized pyrrolizidine progenitors was investigated. | |
| dc.format.medium | masters theses | |
| dc.identifier.uri | https://hdl.handle.net/10217/235859 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation | Catalog record number (MMS ID): 991013435309703361 | |
| dc.relation | RS431.A64K67 2001 | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.subject.lcsh | Pyrrolizidines | |
| dc.subject.lcsh | Antineoplastic agents | |
| dc.title | Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids | |
| dc.type | Text | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Masters | |
| thesis.degree.name | Master of Science (M.S.) |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ETDF_2001_Fa_Kosogof_Christi_DIP.pdf
- Size:
- 17.47 MB
- Format:
- Adobe Portable Document Format