Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT
| dc.contributor.author | Rudroff, Thorsten, author | |
| dc.contributor.author | Kindred, John H., author | |
| dc.contributor.author | Benson, John-Michael, author | |
| dc.contributor.author | Tracy, Brian L., author | |
| dc.contributor.author | Kalliokoski, Kari K., author | |
| dc.contributor.author | Frontiers Media S. A., publisher | |
| dc.date.accessioned | 2007-01-03T06:04:40Z | |
| dc.date.available | 2007-01-03T06:04:40Z | |
| dc.date.issued | 2014-05 | |
| dc.description.abstract | We used positron emission tomography/computed tomography (PET/CT) and [18F]-FDG to test the hypothesis that glucose uptake (GU) heterogeneity in skeletal muscles as a measure of heterogeneity in muscle activity is greater in old than young men when they perform isometric contractions. Six young (26 ± 6 years) and six old (77 ± 6 years) men performed two types of submaximal isometric contractions that required either force or position control. [18F]-FDG was injected during the task and PET/CT scans were performed immediately after the task. Within-muscle heterogeneity of knee muscles was determined by calculating the coefficient of variation (CV) of GU in PET image voxels within the muscles of interest. The average GU heterogeneity (mean ± SD) for knee extensors and flexors was greater for the old (35.3 ± 3.3%) than the young (28.6 ± 2.4%) (P = 0.006). Muscle volume of the knee extensors were greater for the young compared to the old men (1016 ± 163 vs. 598 ± 70 cm3, P = 0.004). In a multiple regression model, knee extensor muscle volume was a predictor (partial r = −0.87; P = 0.001) of GU heterogeneity for old men (R2 = 0.78; P < 0.001), and MVC force predicted GU heterogeneity for young men (partial r = −0.95, P < 0.001). The findings demonstrate that GU is more spatially variable for old than young men and especially so for old men who exhibit greater muscle atrophy. | |
| dc.description.sponsorship | Published with support from the Colorado State University Libraries Open Access Research and Scholarship Fund. | |
| dc.format.medium | born digital | |
| dc.format.medium | articles | |
| dc.identifier.bibliographicCitation | Rudroff, Thorsten, John H. Kindred, John-Michael Benson, Brian L. Tracy, and Kari K. Kalliokoski, Greater Glucose Uptake Heterogeneity in Knee Muscles of Old Compared to Young Men During Isometric Contractions Detected by [18F]-FDG PET/CT. Frontiers in Physiology 5, article 198 (May 2014): 1-8. http://dx.doi.org/10.3389/fphys.2014.00198 | |
| dc.identifier.doi | https://dx.doi.org/10.3389/fphys.2014.00198 | |
| dc.identifier.uri | http://hdl.handle.net/10217/83371 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | Open Access Research and Scholarship Fund (OARS) | |
| dc.rights.license | This article is open access and distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0). | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | glucose | |
| dc.subject | aging | |
| dc.subject | positron emission tomography | |
| dc.subject | muscle volume | |
| dc.subject | computed tomography | |
| dc.title | Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT | |
| dc.type | Text |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Rudroff_FrontiersInPhysiology_2014_OARS.pdf
- Size:
- 990.6 KB
- Format:
- Adobe Portable Document Format
- Description: