Epidithiodioxopiperazines: synthetic studies of (+)-chetomin and (-)-sporidesmin A
| dc.contributor.author | Welch, Timothy R., author | |
| dc.contributor.author | Williams, Robert M., advisor | |
| dc.contributor.author | Rovis, Tomislav, committee member | |
| dc.contributor.author | Wood, John L., committee member | |
| dc.contributor.author | Ackerson, Chris, committee member | |
| dc.contributor.author | Thamm, Douglas H., committee member | |
| dc.date.accessioned | 2007-01-03T08:26:29Z | |
| dc.date.available | 2014-01-01T08:10:42Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | This dissertation documents efforts toward the asymmetric total syntheses of the natural products (+)-chetomin and (-)-sporidesmin A. Synthetic methods have been developed to efficiently construct the dioxopiperazine core of both molecules. Additionally, a simple epidithiodioxopiperazine has been synthesized to demonstrate a general method for the addition of a sulfur bridge to a dioxopiperazine ring. The work described herein, while not totally successful, provides a basis for future completion of the asymmetric total syntheses of these two epidithiodioxopiperazines and other related fungal metabolites. | |
| dc.format.medium | born digital | |
| dc.format.medium | doctoral dissertations | |
| dc.identifier | Welch_colostate_0053A_11366.pdf | |
| dc.identifier | ETDF2012500342CHEM | |
| dc.identifier.uri | http://hdl.handle.net/10217/71601 | |
| dc.language | English | |
| dc.language.iso | eng | |
| dc.publisher | Colorado State University. Libraries | |
| dc.relation.ispartof | 2000-2019 | |
| dc.rights | Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. | |
| dc.title | Epidithiodioxopiperazines: synthetic studies of (+)-chetomin and (-)-sporidesmin A | |
| dc.type | Text | |
| dcterms.embargo.expires | 2014-01-01 | |
| dcterms.embargo.terms | 2014-01-01 | |
| dcterms.rights.dpla | This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| thesis.degree.discipline | Chemistry | |
| thesis.degree.grantor | Colorado State University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Doctor of Philosophy (Ph.D.) |
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