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Development and thermal characterization of polydiacetylene (PDA) nanofiber composites for smart wound dressing applications

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dc.contributor.authorAlam, A K M Mashud, author
dc.contributor.authorLi, Yan Vivian, advisor
dc.contributor.authorPark, Juyeon, committee member
dc.contributor.authorGentry-Weeks, Claudia, committee member
dc.date.accessioned2016-08-18T23:10:25Z
dc.date.available2016-08-18T23:10:25Z
dc.date.issued2016
dc.description.abstractConventional methods of identification of microbiological pathogens infection in wound have many challenges such as the need for specialized instruments and trained personnel, and the long detection time. There is a critical need for an innovative method that is simple, accurate, sensitive, reliable, and rapid in pathogen detection practices. Wound dressings containing PDA nanofibers could be used as a diagnostic tool for the detection of onsite bacterial infection. By early wound infection diagnosis, the smart wound dressing would allow physicians to start timely treatment which would reduce hospitalization time and patient suffering. PDAs are of great interest in the development of chromatic sensors due to their unique optical property of undergoing a chromatic transition from blue to red upon external stimuli. 10,12-Pentacosadiynoic acid (PCDA) and poly (ethylene oxide) (PEO) were used in this study to develop fiber composites via an electrospinning method at various mass ratios of PEO to PCDA, solution concentrations, and injection speeds. High mass ratios of PEO to PCDA, low polymer concentrations, and low injection speed promoted fine fibers with smooth surfaces. The colorimetric transition of the fibers was investigated by heating the fibers at temperatures ranging from 25 °C to 120 °C. A color switch from blue to red was observed when the fibers were treated at temperatures higher than 60 °C. The color transition was more sensitive in the fibers made with a low mass ratio of PEO to PCDA due to the high fraction of PDA in the fibers. The large diameter fibers also promoted the color switch due to the high reflectance area in the fibers. All of the fibers were analyzed using Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) and compared before and after the color change occurred. The colorimetric transitional mechanism is proposed to occur due to conformational changes in the PDA macromolecules.
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierAlam_colostate_0053N_13770.pdf
dc.identifier.urihttp://hdl.handle.net/10217/176730
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2000-2019
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.subjectcharacterization
dc.subjectnanofiber
dc.subjectwound dressing
dc.subjectelectrospinning
dc.subjectbiosensor
dc.subjectpolydiacetylene
dc.titleDevelopment and thermal characterization of polydiacetylene (PDA) nanofiber composites for smart wound dressing applications
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineDesign and Merchandising
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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