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Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans

dc.contributor.authorReed, Kailee Janelle, author
dc.contributor.authorMontgomery, Taiowa A., advisor
dc.contributor.authorWilusz, Carol J., committee member
dc.contributor.authorNishimura, Marc T, committee member
dc.contributor.authorHoerndli, Fred J., committee member
dc.date.accessioned2022-05-30T10:21:07Z
dc.date.available2022-05-30T10:21:07Z
dc.date.issued2022
dc.description2022 Spring.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThere are three distinct classes of small RNAs found in animals: microRNAs (miRNAs), piwi interacting RNAs (piRNAs), and small interfering RNAs (siRNAs). miRNAs are required throughout development, whereas piRNAs and siRNAs are best known for their roles in germline development and genome defense (see Chapter 1 for an overview of piRNA and siRNA pathways). To identify the roles of piRNAs and siRNAs in regulating gene expression in the germ cells of Caenorhabditis elegans, we subjected small RNAs and messenger RNAs (mRNAs) from the distal gonads of piRNA and siRNA mutants to high-throughput sequencing. We identified extensive roles for piRNAs and siRNAs in regulating gene expression during germline development, including an unexpected role for piRNAs in preventing histone silencing by the siRNA pathway (see Chapter 2).
dc.format.mediumborn digital
dc.format.mediummasters theses
dc.identifierReed_colostate_0053N_17020.pdf
dc.identifier.urihttps://hdl.handle.net/10217/235162
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.relation.ispartof2020-
dc.rightsCopyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.
dc.titleRoles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans
dc.typeText
dcterms.rights.dplaThis Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
thesis.degree.disciplineCell and Molecular Biology
thesis.degree.grantorColorado State University
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (M.S.)

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