Two model systems for studying the effects of acute radiation exposure on gene deletions and amplifications
Ionizing radiation (IR) poses a severe threat to genome integrity, and is an important source of environmental damage, arising from naturally occurring sources (e.g. radon and cosmic radiation) and medical imaging and therapy. Radiation exposure can lead to somatic changes in chromosomal structure such as copy number alterations (CNAs) resulting in gain or loss in copies of sections of DNA. To study copy number alterations in the human genome resulting from gamma radiation, early passage cultures of normal human fibroblasts were exposed to a single acute 4 Gy dose of radiation. Irradiated cells ...
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