Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches. Survivin, an IAP (inhibitor of apoptosis) family member protein that inhibits apoptosis and drives cell proliferation, is commonly elevated in human and canine cancer. Survivin expression is a negative prognostic factor in both dogs and humans with LSA and OS, and canine LSA and OS cell lines express high levels of survivin. Due to the strong similarities between canine and human LSA and OS, canine LSA and OS are excellent models for the human disease. In the ...
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