Development and application of an improved in vitro model for aerosol toxicology
In vitro cellular studies offer an economical and rapid screening tool for assessing aerosol toxicity. Traditional submerged in vitro cell models and exposure techniques are often criticized for their inability to (1) simulate in vivo cellular morphology (2) maintain the chemical and physical characteristics of sampled aerosol and (3) estimate 'delivered' exposure levels. Further, the exposure levels applied in traditional submerged in vitro systems are often orders of magnitude above inhalational exposures that occur in vivo. Improved airway cell culture models and direct air-to-cell exposure ...
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