Semiparametric regression in the presence of complex variance structures arising from small angle x-ray scattering data
An ongoing problem in structural biology is how best to infer structural information for complex, biological macromolecules from indirect observational data. Molecular shape dictates functionality but is not always directly observable. There exists a wide class of experimental methods whose data can be used for indirectly inferring molecular shape features with varying degrees of resolution. Of these methods, small angle X-ray scattering (SAXS) is desirable due to low requirements on the sample of interest. However, SAXS data suffers numerous statistical problems that require the development of ...
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