Characterization of HIV-1 protease autoprocessing trans-cleavage mechanism
HIV protease is an aspartic acid enzyme responsible for the cleavage reactions essential in the maturation (infectivity) of the viral particle. Protease inhibitors (non-cleavable substrate analogs) have been potent tools in combating HIV infection as well as its result - AIDS. However, the emergence of drug-resistant viruses in patients treated with these inhibitors is an ongoing concern. Thus there is a growing need to find additional therapeutic targets and treatments to supplement the currently available protease inhibitors. A promising new target for drug development is protease autoprocessing ...
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