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    Protein synthesis in slowed aging: insights into shared characteristics of long-lived mouse models

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    http://hdl.handle.net/10217/82613
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    Abstract
    The following dissertation describes a series of experiments with the overall aim to understand the role that changes in protein synthesis have in slowed aging. The specific aims of the three sets of experiments were 1) to determine if chronic administration of the mTORC1 inhibitor rapamycin to mice increases proteostatic mechanisms in skeletal muscle, heart, and liver; 2) to determine if an underdeveloped anterior pituitary, caused by deletion of the Pit-1 gene in mice, increases proteostatic mechanisms in skeletal muscle, heart, and liver of long-lived Snell dwarf mice; 3) and to determine ...
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    Author(s)
    Drake, Joshua Chadwick

    Advisor(s)
    Miller, Benjamin F.; Hamilton, Karyn L.

    Date Issued
    2014
    Format
    born digital; doctoral dissertations
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    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Health and Exercise Science

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