Role of the sympatho-adrenal system in the regulation of peripheral vascular tone in healthy aging humans
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The following dissertation is comprised of a series of experiments with the overall aim of determining the role of the sympatho-adrenal system in the regulation of peripheral vascular tone in normal, healthy aging humans. Aging is associated with a reduction in aerobic capacity and elevated risk of cardiovascular disease. The decline in aerobic capacity could be a consequence of impaired O2 delivery, directly attributed to attenuated skeletal muscle blood flow. Attenuated skeletal muscle blood flow reflects a decline in the ability to adequately regulate peripheral vascular tone, either due ...