Mechanisms of pulmonary fibrosis in PECAM-1 deficient FVB/n mice
Idiopathic Pulmonary Fibrosis (IPF) is a fatal disease of the aging population that affects nearly 100,000 Americans, and its incidence has been steadily on the increase. Patients typically present in late-stage disease, and effective early stage diagnosis and treatment methods are thoroughly lacking. The cellular and molecular events involved in disease initiation are still unknown. There is increasing evidence that alveolar bleeding and coagulation play an important role in the initiation and progression of IPF, and anticoagulant therapies have been shown to exacerbate the process of the ...