Role of neuroinflammatory NF-KB signaling and glial crosstalk in neurodegeneration, The
Neuroinflammation or inflammatory activation of astrocytes and microglia are considered pathological hallmarks and important mechanisms in debilitating neurodegenerative diseases. However, the signaling mechanisms underlying these neuroinflammatory changes are not fully understood and there is evidence that these inflammatory responses can serve both neuroprotective and neurotoxic roles. Few studies have begun to study the complicated communications occurring between activated glia and the contributions of these cells to neuronal injury. Furthermore, the importance of these pathways in ...
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