Structure-function relationships underlying GluA2 mechanisms of deactivation, desensitization, and modulation
Glutamate is the primary excitatory neurotransmitter in the central nervous system, where it is principally responsible for mediating excitatory neurotransmission. Ligand-gated receptors to glutamate, such as the a-amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA) receptor, are responsible for many cognitive processes; with the AMPA receptor showing an essential role in learning, memory, and synaptic plasticity. As many mental illnesses and diseases show underlying cognitive complications, therapeutic drugs that can alleviate these cognitive deficits show tremendous potential benefit. ...
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