Modeling dengue viral infection, insect transmission and multiplex PCR in humanized mice
Due to the restricted host specificity of dengue virus, up until now no ideal animal model has sufficiently mimicked key aspects of viral pathogenesis and immune response. In this regard, new advances with humanized mice(hu-mice), constructed by engrafting human tissues and cells and harboring a functioning human immune system, have been of great value in advancing research with human viruses Here we sought to utilize hu-mice to understand natural dengue pathogenesis and immune response. RAG1-/- γc-/- or RAG2-/- γc-/- mice are immune-compromised and do not reject foreign grafts. This ...
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