Synthetic strategies toward the total synthesis of tetrapetalone A
In 2003 Hirota and coworkers reported the isolation of tetrapetalone A (1) from the culture filtrate of Streptomyces sp. USF 4727, a Streptomyces strain isolated from a soil sample taken from Yada, Shizuoka City, Japan. The molecular structure of 1 was initially reported and then revised in a series of two papers which both appeared in 2003. In addition to the interesting molecular architecture, 1 demonstrated inhibition of soybean lipoxygenase (SBL) (IC50 of 190 μM) comparable to well-known human lipoxygenase and cyclooxygenase inhibitors. While no total synthesis has been reported to date, ...
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