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    Synthetic strategies toward the total synthesis of tetrapetalone A

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    http://hdl.handle.net/10217/71566
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    Howell_colostate_0053A_11435.pdf (9.230Mb)
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    Abstract
    In 2003 Hirota and coworkers reported the isolation of tetrapetalone A (1) from the culture filtrate of Streptomyces sp. USF 4727, a Streptomyces strain isolated from a soil sample taken from Yada, Shizuoka City, Japan. The molecular structure of 1 was initially reported and then revised in a series of two papers which both appeared in 2003. In addition to the interesting molecular architecture, 1 demonstrated inhibition of soybean lipoxygenase (SBL) (IC50 of 190 μM) comparable to well-known human lipoxygenase and cyclooxygenase inhibitors. While no total synthesis has been reported to date, ...
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    Author(s)
    Howell, Jennifer Marie

    Advisor(s)
    Wood, John L.

    Date Issued
    2012
    Format
    born digital; doctoral dissertations
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    • 2000-2019 - CSU Theses and Dissertations
    • Theses and Dissertations - Department of Chemistry

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