Characterizing the role of the HspX protein from Mycobacterium tuberculosis as a subunit vaccine candidate in the small animal model of tuberculosis
Tuberculosis (TB) is a bacterial disease of the lung, caused by Mycobacterium tuberculosis, and currently remains an important human pathogen. The only vaccine against tuberculosis licensed for human use is a live, attenuated strain of the closely related Mycobacterium bovis Bacille-Calmette Guerin (BCG), which offers little protection against pulmonary disease in adults, particularly against latent infection. Current vaccine strategies against TB include the development of subunit vaccines, which contain one to a few antigens. Subunit vaccines are delivered with an adjuvant formulation to mount ...
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