Development of ligands for C-H functionalization utilizing amino acid derived directing groups, The
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Abstract
The functionalization of unreactive bonds has become a focus of new reaction methodology. The foremost difficulty lies within achieving high levels of chemo-, regio-, and stereoselectivity without the need for molecular complexity. The aim of my project was to develop a catalyst system that could direct a C-H functionalization by forming a transient covalent attachment to a simple substrate and release the substrate after the transformation. I have developed two asymmetric catalysts for the C-H acetoxylation of sp3 and sp2 bonds. The sp3 C-H acetoxylation occurs with high levels of ...
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