The progress towards the total synthesis of (ent)-MPC1001
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Herein are my efforts toward the total synthesis of (ent)-MPC1001, beginning with the development of a novel asymmetric [1-3]-dipolar cycloaddition utilizing a vinyl silane and a chiral lactone template. The mechanism of the cycloaddition was investigated and the cyclized product can be elaborated in 6 steps to the A-B-C ring system of the MPC family of natural products. However, the key ring-closing metathesis reaction provided irreproducible results. Therefore, a macrolactonization was utilized to synthesize an advanced lactone derivative. Current research is focused on the elaboration of the ...