Development of an in vitro model of functional mitral valve regurgitation
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Functional or ischemic mitral regurgitation (FMR) is a common sequelae to various cardiomyopathies which result in altered cardiac geometry secondary to ventricular remodeling. The causative architectural changes are typified by apical tethering of the mitral valve leaflets by ventricular dilation and papillary muscle repositioning, and is usually accompanied by annular dilation and mitral valve leaflet malcoaptation. The resultant mitral regurgitation (MR) and consequent volume overload contributes to further ventricular remodeling and perpetuation of the clinical scenario. The present mainstay ...
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Development of an ex vivo pulsatile heart model of functional mitral regurgitation to facilitate posterior papillary muscle geometric studies and subvalvular surgical strategy Contributor:Kradangnga, Krishaporn;
Date Submitted:2018Surgical method of choice for functional ischemic mitral regurgitation (FIMR) is debatable, since recurrence of FIMR post-annuloplasty has been reported in significant number of cases. Developing an ex vivo pulsatile ...
Insights into the origins of functional mitral regurgitation and development of a corrective epicardial device Contributor:Gleyzolle, Baptiste;
Date Submitted:2010Functional mitral regurgitation (FMR) is a frequent complication of left ventricular remodeling and carries a significant adverse prognosis. While significant progress has recently been made in the understanding of the ...
Connecting Structural Changes to Cell Transformation Patterns in the Canine Degenerative Mitral Valve Contributor:Abbott, Kaitlin Marie;
Date Submitted:2015Degenerative mitral valve disease (DMVD) is a significant problem in the canine population and also affects humans. Recent studies have provided insight into molecular and cellular mechanisms that likely contribute to ...