Relationship between nicotine and neurophysiology in schizophrenia, The
Abnormalities of the nicotinic cholinergic system in the brain have been noted in a number of clinical disorders. The higher than average rate of smoking in clinical populations has been theorized as being related to abnormalities in this system. In schizophrenia, the rate of smoking surpasses that of other clinical populations (approximately 80-90% compared to 45-70%). The high rate of smoking, evidence of genetic linkage of schizophrenia to specific nicotinic receptors, and evidence for positive neuropsychological effects of nicotine, all suggest that nicotinic cholinergic mechanisms may play ...
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