Francisella tularensis: host-pathogen responses to infection and drug target identification
The pathobiology of the host and pathogen responses to Francisella tularensis infection and disease progression were poorly understood when I started my graduate career. To address this, we have employed an integrative biological approach consisting of monitoring of the host transcriptional response to infection and dissemination, and determining the transcriptionally active and essential genes required for F. tularensis infection and disease progression. Drug therapies for F. tularensis that control the dissemination of the bacterium from the lungs to the spleen, liver, and kidneys are associated ...
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